1. Correct: My brother Humperdinck might rule the all of Florin someday.
Explanation: Since "Humperdinck" is a one-word appositive, no commas are necessary.
2. Wrong: Her car the Ford F-150 with huge tires is in the shop.
Better: Her car, the Ford F-150 with huge tires, is in the shop.
Explanation: Even if she has two Ford F-150s, a fact which would make the "with huge tires" essential to the reader's understanding of which car the speaker is talking about, the commas still help clarify that the independent clause says, "Her car is in the shop."
3. Wrong: Preps find taking the four Grammar Gateways best four classes of the year both challenging and enjoyable.
Better: Preps find taking the four Grammar Gateways, best four classes of the year, both challenging and enjoyable.
Explanation: separating the appositive with commas makes the sentence clearer.